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While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it Phenergan on the other hand despite issues with it causes intense sedation, mild akathisia and burning on injection seems to be the "golden ticket" in terms of anti-emetics and rarely seems to fail to do its job unless the etiology of vomiting is unknown and requires multiple antiemetics that hit multiple targets in the brain Promethazine is an antihistamine medicine that relieves the symptoms of allergies. Will phenergan help diarrhea? 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