Chloroquine In Cancer Therapy A Double-edged Sword Of Autophagy
Chloroquine (CQ), an autophagy inhibitor, has been demonstrated to increase the efficacy of chemotherapy in treating several solid tumors, such as hepatocellular carcinoma, breast cancer, and hypopharyngeal carcinoma.16–18 Recent studies on drug resistance mechanisms indicate that the antitumor-augmenting efficacy of CQ is largely due to its autophagy-inhibiting …. Levine, B. Autophagy is a double-edged sword and can autophagy inhibitors, such as chloroquine or R. S. Debnath J. Chloroquine (CQ) is an anti-malarial drug, and is also known as an inhibitor of autophagy Oct 01, 2014 · Chloroquine is an antimalarial drug that has been used in humans for many years . Chloroquine (CQ) is an anti-malarial drug, and is also known as an inhibitor of autophagy. It is a recombinant antibody reacting with Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) and identified with ELISA Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment Liang Qin,1,* Tianyuan Xu,1,* Leilei Xia,1 Xianjin Wang,1 Xiang Zhang,1 Xiaohua Zhang,1 Zhaowei Zhu,1 Shan Zhong,1 Chuandong Wang,2 chloroquine in cancer therapy a double-edged sword of autophagy Zhoujun Shen1 1Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, …. As such, autophagy is tumor suppressive Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. autophagy in cancer is highly complex and still paradoxical. Importantly, they demonstrated that autophagy blockade via chloroquine (CQ) or hydroxychloroquine (HCQ) enhanced the efficacy of MEK–ERK inhibition in various preclinical models of KRAS-driven cancers, providing a rational basis for future clinical evaluation of this combination therapy. Article Sections. Chloroquine (CQ), an antimalarial agent, is able to induce sustained chloroquine in cancer therapy a double-edged sword of autophagy endoplasmic reticulum (ER) stress by functioning as an autophagy inhibitor. Cited by: 401 Publish Year: 2013 Author: Tomonori Kimura, Yoshitsugu Takabatake, Atsushi Takahashi, Yoshitaka Isaka [PDF] Chloroquine in Cancer Therapy: A Double-Edged Sword of https://cancerres.aacrjournals.org/content/canres/73/1/3.full.pdf cesses of autophagy is a more preferable approach in cancer therapy, however, and is now under investigation (28). The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. Accordingly, autophagy becomes a potential target for. 7,. Autophagy in tumor suppression and cancer therapy. Figure 1. It is worth to note that autophagy is a double-edged sword in the initiation, development, and metastasis of cancer . Jan 16, 2018 · “Our findings reveal that conventional cancer therapy is essentially a double-edged sword,” says co-senior author on the study Mark Kieran, MD, PhD, who directs the Pediatric Brain Tumor Program at Dana-Farber/Boston Children’s and is an associate professor of pediatrics at Harvard Medical School. To determine the biological role of autophagy in cell survival or death, the autophagy inhibitor CQ was utilized to block the autophagic process in the colorectal cancer cells Purchase anti-S Antibody from Cusabio.
Hydroxychloroquine drug, sword autophagy a in double-edged cancer therapy of chloroquine
73:3–7. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers.. And Kroemer, G. 3-7. The roles of therapy-induced autophagy and necrosis in cancer treatment Jun 24, 2017 · Autophagy can be a double-edged sword for MDR tumors: it participates in the development of MDR and protects cancer cells from chemotherapeutics but can also kill MDR cancer cells in which apoptosis pathways are inactive In particular, the autophagy inhibitors chloroquine and hydroxychloroquine, commonly used antimalarial drugs, are currently being investigated in phase I and phase II trials in patients with glioblastoma and myeloma. Debnath J. However, increased induction of autophagy can become a mechanism which allows tumor cells to survive the conditions of hypoxia, acidosis, or chemotherapy. Double‐blind Trial Evaluating the Effects of Chloroquine in Breast Cancer cancer cell autophagy and TFEB activity can be modeled in three‐dimensional growth conditions. Dec 19, 2017 · Dual role of autophagy in hallmarks of cancer. Autophagy and metastasis: another double-edged sword Chloroquine (CQ), an autophagy inhibitor, Isaka Y. In spite of this, inhibition of autophagy in the clinic can behave as a double-edged sword because it can enhance or suppress cancer immune response According to current research, autophagy inhibition has been applied to a variety of cancer therapies, such as glioma, myeloma, breast cancer, rectal cancer, and prostate cancer . 2013. To the best of our knowledge, no studies to date have examined the potential for CQ to provide neuroprotection in animal models of traumatic brain injury (TBI) Aug 02, 2016 · Autophagy plays a crucial role in cancer cell survival and the inhibition of autophagy is attracting attention as an emerging strategy for the treatment of cancer. Mice with neuron-specific knock out of the core autophagy protein, ATG7, are viable but most go on to develop behavioral defects and eventually massive neuronal loss in the cerebral corticies 1 However, autophagy has been referred to as a double-edged sword because in certain cellular contexts, exces-sive or sustained tumor cell autophagy may be prodeath, particularlyinapoptosis-defectivecells(10).Understand-ing the role of autophagy in cancer treatment is critical, because many anticancer therapies have been shown. The present study investigated the interaction of zinc ions with chloroquine in a human ovarian cancer cell …. 264 In many cell types, though, especially. Recycling old and damaged cellular material. Autophagy plays a crucial role in cancer cell survival and the inhibition of autophagy is attracting attention as an emerging strategy for the treatment of cancer. Jun 14, 2019 · Based on this knowledge, in vivo studies have started to employ autophagy inhibitors, such as inhibitors of the lysosomal protease and anti-malaric drugs, Chloroquine (CQ) or Hydroxichloroquine (HCQ), to treat cancer, more often in combination with chemotherapies able to induce autophagy [17,18,19] Mar 15, 2018 · Therefore, in contrast to exosomes from other sources used to deliver therapeutic agents, tumor exosomes may be a double-edged sword when used as a therapeutic tool for cancer treatment In support of this notion, autophagy inhibition by 3-methyladenine (3-MA), chloroquine (CQ, a lysosomotropic agent to inhibit autophagolysosome formation) and autophagy (ATG)-related gene 5 silencing was found to augment the cytotoxic effects by chemotherapies and target therapy [11–16]. “But more importantly, we also found a. Keywords: Autophagy, chloroquine in cancer therapy a double-edged sword of autophagy cancer, ATG, ULK inhibitor, Vps34 inhibitor, mammalian target of rapamycin inhibitors,. Recently, modulating autophagy by pharmacological agents has become an attractive strategy to treat cancer. Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways. Originally, mitochondria have been derived from bacteria. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. In this case, autophagy is detrimental to DR treatment , suggesting that autophagy might be a potential target to treat DR. Autophagy Aug 02, 2016 · Autophagy chloroquine in cancer therapy a double-edged sword of autophagy plays a crucial role in cancer cell survival and the inhibition of autophagy is attracting attention as an emerging strategy for the treatment of cancer. It appears to have the double -edged sword effect: Under stress circumstances, autophagy can protect cancer cells against apoptosis and/or other forms of cell death by providing energy and essential macromolecules, whereas excessive autophagy may cause irreversible self-destruction of. Although autophagy acts as a “double-edged sword” in tumorigenesis , autophagy acts more as a cytoprotective mechanism in tumor therapy Oxidative Medicine and Cellular Longevity / 2018 / Article. autophagy can have no effect on cancer therapy ("nonprotective" autophagy) [10,11]. The method comprises contacting a population of cells comprising cancer cells that are nonresponsive to chloroquine, or a salt or prodrug thereof, and normal cells that are responsive to chloroquine, or a salt or prodrug thereof, with an effective amount of chloroquine, or salt or prodrug thereof, wherein treatment with the effective amount of chloroquine, or salt chloroquine in cancer therapy a double-edged sword of autophagy or prodrug …. Thus, ISG15 clearly has double-edged functions in malignant disease and proper consideration must be given in order to assess risk-beneﬁt prior to admin-istering ISG15-targeted cancer therapy. Therefore, efforts to understand and modulate the autophagy pathway will provide new approaches to cancer therapy and prevention. and DiPaola, R. 73.